BCL10 is rarely mutated in human prostate carcinoma, small-cell lung cancer, head and neck tumours, renal carcinoma and sarcomas

We have used single-strand conformation polymorphism (SSCP) analysis to scr een for mutations in the BCL10 gene in 81 primary prostate carcinomas, 20 s quamous cell cancers of the head and neck, 15 small-cell lung cancer cell l ines, 24 renal carcinoma cell lines and 13 sarcoma cell lines. We failed to find evidence of somatically acquired mutations of the BCL10 gene suggesti ng that BCL10 does not play a major role in the development of these malign ancies.