Bcl10 is not a target for frequent mutation in human carcinomas

The recently described Bcl10 gene has been suggested to be a major target g ene for inactivation in a variety of human cancers. In order to further eva luate the role of this gene in human adult malignancies, we have analysed a series of carcinomas for mutations in the Bcl10 gene. We have screened a p anel of 174 carcinoma samples in total, comprised of 47 breast, 36 epitheli al ovarian, 36 endometrial, 12 cervical, 23 colorectal and 20 head/neck car cinomas, all unselected for grade or stage. This panel reflects, in part, t umours reported to have involvement of the 1p22 region of chromosome 1, the region harbouring the Bcl10 gene. No deleterious mutations were detected i n any of the samples analysed, strongly suggesting that Bcl10 is not a comm on target for inactivation in adult malignancies and that BCL10 is not the gene targeted for frequent inactivation at 1p22.