Significance of serum-soluble CD95 (Fas/APO-1) on prognosis in renal cell cancer patients

Authors
Kimura, M Tomita, Y Imai, T Saito, T Katagiri, A Tanikawa, T Takeda, M Takahashi, K
Citation
M. Kimura et al., Significance of serum-soluble CD95 (Fas/APO-1) on prognosis in renal cell cancer patients, BR J CANC, 80(10), 1999, pp. 1648-1651
Citations number
15
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
BRITISH JOURNAL OF CANCER
ISSN journal
00070920 → ACNP
Volume
80
Issue
10
Year of publication
1999
Pages
1648 - 1651
Database
ISI
SICI code
0007-0920(199907)80:10<1648:SOSC(O>2.0.ZU;2-N
Abstract
Serum-soluble CD95 (sCD95) levels for 72 renal cell cancer patients were si gnificantly higher than those of 17 healthy donors. Twenty-one of 72 patien ts had elevated (defined as more than mean of healthy donors + 2 s.d.) sCD9 5. The disease-specific survival rate was significantly lower in the elevat ed sCD95 group. Serum sCD95 level was shown to be an independent prognostic factor by univariate and multivariate analysis, indicating a possible sign ificant role in determining treatment strategies.