Clinical implication of expression of platelet-derived endothelial cell growth factor (PD-ECGF) in metastatic lesions of uterine cervical cancers

The platelet-derived endothelial cell growth factor (PD-ECGF) level was sig nificantly (P < 0.05) increased in 8 of 40 metastatic lymph node lesions of uterine cervical cancers. The prognosis of the eight patients with high PD -ECGF (>10,000 pg/mg protein) in metastatic lymph node lesions was extremel y poor. On the other hand, the 24-month survival rate of the 32 patients wi th low PD-ECGF (<10,000 pg/mg protein) in metastatic lymph node lesions was 75%. This indicates that PD-ECGF may contribute to the advancement of meta static lesions, a:nd that the PD-ECGF level in metastatic lesions may be a prognostic indicator.