Multiple site dioxygenase-catalysed cis-dihydroxylation of polycyclic azaarenes to yield a new class of bis-cis-diol metabolites

Authors
Boyd, DR Sharma, ND Carroll, JG Allen, CCR Clarke, DA Gibson, DT
Citation
Dr. Boyd et al., Multiple site dioxygenase-catalysed cis-dihydroxylation of polycyclic azaarenes to yield a new class of bis-cis-diol metabolites, CHEM COMMUN, (13), 1999, pp. 1201-1202
Citations number
21
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
13
Year of publication
1999
Pages
1201 - 1202
Database
ISI
SICI code
1359-7345(19990707):13<1201:MSDCOP>2.0.ZU;2-B
Abstract
The enhanced stability of new mono-cis-dihydrodiol bacterial metabolites of tricyclic azaarenes has facilitated the dioxygenase-catalysed formation an d isolation of the corresponding bis-cis-dihydrodiols (cis-tetraols) and a three step chemoenzymatic route to the derived arene oxide mammalian metabo lites.