EFFECT OF FISH-OIL ON INDOMETHACIN-INDUCED GASTRIC-LESIONS IN RATS

Authors
GUZEL C ULAK G SERMET A CICEK R ULAK M
Citation
C. Guzel et al., EFFECT OF FISH-OIL ON INDOMETHACIN-INDUCED GASTRIC-LESIONS IN RATS, Arzneimittel-Forschung, 45-2(11), 1995, pp. 1172-1173
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Arzneimittel-Forschung → ACNP
ISSN journal
00044172
Volume
45-2
Issue
11
Year of publication
1995
Pages
1172 - 1173
Database
ISI
SICI code
0004-4172(1995)45-2:11<1172:EOFOIG>2.0.ZU;2-A
Abstract
The effect of fish oil in promoting the healing of indometacin-induced gastric lesions was investigated in Wistar albino rats, After indomet acin treatment (30 mg/kg, s.c.), animals were given fish oil, olive oi l, or normal diet for 48 h. Thr ulcer index was found to be decreased to 2.1 +/- 1.8 mm with fish oil 13.7 +/- 5.4 mm with olive oil, and 14 .6 +/- 2.4 mm with normal diet. Fish oil showed a potent healing-promo ting effect on acute gastric erosions and ulcers induced by indometaci n anti significantly, enhanced the mucus content of the mucosa (p < 0. 05).