Molecular dynamics simulation of site-directed mutagenesis of HIV-1 Tat trans-activator

Authors
Cui, Y Ling, LJ Chen, RS Bai, LC Yuan, JG Qiang, BQ
Citation
Y. Cui et al., Molecular dynamics simulation of site-directed mutagenesis of HIV-1 Tat trans-activator, CHIN SCI B, 44(8), 1999, pp. 708-711
Citations number
6
Categorie Soggetti
Multidisciplinary
Journal title
CHINESE SCIENCE BULLETIN
ISSN journal
10016538 → ACNP
Volume
44
Issue
8
Year of publication
1999
Pages
708 - 711
Database
ISI
SICI code
1001-6538(199904)44:8<708:MDSOSM>2.0.ZU;2-L
Abstract
The Cys-rich domain, core region and basic domain are highly conserved and very important to the trans-activation activity of HIV-I Tat trans-activato r. The three-dimensional structures of 6 mutants of HIV-1 Tat protein were constructed with the methods of molecular dynamics simulation. The variatio ns of the structures of the mutants have been analyzed and the factors that led to abolishment of trans-activation activity have been discussed.