Assignment of human teratocarcinoma derived growth factor (TDGF) sequencesto chromosomes 2q37, 3q22, 6p25 and 19q13.1

Authors
Scognamiglio, B Baldassarre, G Cassano, C Tucci, M Montuori, N Dono, R Lembo, G Barra, A Lago, CT Viglietto, G Rocchi, M Persico, MG
Citation
B. Scognamiglio et al., Assignment of human teratocarcinoma derived growth factor (TDGF) sequencesto chromosomes 2q37, 3q22, 6p25 and 19q13.1, CYTOG C GEN, 84(3-4), 1999, pp. 220-224
Citations number
13
Categorie Soggetti
Molecular Biology & Genetics
Journal title
CYTOGENETICS AND CELL GENETICS
ISSN journal
03010171 → ACNP
Volume
84
Issue
3-4
Year of publication
1999
Pages
220 - 224
Database
ISI
SICI code
0301-0171(1999)84:3-4<220:AOHTDG>2.0.ZU;2-C
Abstract
The human teratocarcinoma derived growth factor 1 (TDGF1) gene maps on chro mosome (Chr) 3p21.3. One pseudogene (TDGF3) maps on Chr Xq21 --> q22. We no w report the nucleotide sequence and chromosome location of three additiona l TDGF pseudogenes. The three new sequences (TDGF2, TDGF4 and TDGF5) are tr uncated at the 5' end and have accumulated several point mutations, deletio ns and insertions. TDGF?, TDGF4 and TDGF6 map on Chrs 2q37, 6p25 and 3q22, respectively. Finally, Southern blot analysis of DNA from normal individual s shows a highly variable restriction pattern of the TDGF sequences.