SYNTHESIS AND INHIBITORY EFFECTS OF 2-PYRIDYL-2-THIOBENZOXAZOLE AND 2-PYRIDYL-2-THIOBENZIMIDAZOLE DERIVATIVES ON ARACHIDONIC-ACID METABOLISM

Authors
LAGORCE JF FATIMI J LAKHDAR M CHABERNAUD ML BUXERAUD J RABY C
Citation
Jf. Lagorce et al., SYNTHESIS AND INHIBITORY EFFECTS OF 2-PYRIDYL-2-THIOBENZOXAZOLE AND 2-PYRIDYL-2-THIOBENZIMIDAZOLE DERIVATIVES ON ARACHIDONIC-ACID METABOLISM, Arzneimittel-Forschung, 45-2(11), 1995, pp. 1207-1210
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Arzneimittel-Forschung → ACNP
ISSN journal
00044172
Volume
45-2
Issue
11
Year of publication
1995
Pages
1207 - 1210
Database
ISI
SICI code
0004-4172(1995)45-2:11<1207:SAIEO2>2.0.ZU;2-5
Abstract
A series of new 2-pyridyl-2-thiobenzoxazole and 2-pyridyl-2-thiobenzim idazole compounds was prepared and investigated by a number of in vitr o methods in order to determine their prostaglandin synthesis inhibito ry activity. The most active compound decreases prostaglandin producti on and carregeenin edema, but has a less platelet antiaggregatory acti vity.