In vitro antibacterial effect of RC-Prep components on Streptococcus sobrinus

The aim of this study was to examine the bacteriostatic and bactericidal ef fects of the components of RC-Prep: EDTA, urea peroxide and glycol. The min imal inhibitory concentration and the minimal bactericidic concentration of EDTA, urea peroxide and glycol were tested bn the viability of Streptococc us sobrinus (S. sobrinus). The combined antibacterial effect of these compo nents was also examined on S. sobrinus. The minimal inhibitory concentratio n of EDTA was found to be 0.125%, of urea peroxide 0.25%, and of glycol 30% . The minimal bactericidic concentration of EDTA was 0.25%, of urea peroxid e 0.5% and of glycol 50%. An antibacterial synergistic effect was found bet ween specific combinations of urea peroxide, EDTA and glycol. No antagonist ic effects were found in the various combinations between the components. T he antimicrobial effect of the components of RC-Prep was enhanced in specif ic combinations of the ingredients. This effect might contribute to the int racanal cleansing properties of this medication.