Vl. Buettner et al., Tandem-base mutations occur in mouse liver and adipose tissue preferentially as G : C to T : A transversions and accumulate with age, ENV MOL MUT, 33(4), 1999, pp. 320-324
Tandem-base mutations (TBM) are associated with ultraviolet light and other
mutagens. Herein, we report an age- and tissue-specific difference in the
frequency of spontaneous TBM in Big Blue(R) transgenic mice. A total of 390
mutants from liver and adipose tissue contained 17 and 4 TBM, respectively
, while no TBM were detected in 683 mutants from six other tissues. There w
as a proportional increase in the frequency of TBM in liver with age (29 da
ys postconception to 25 months of age). Nine TBM (43%) were GG to TT transv
ersions that preferentially occurred at specific sites. The remaining 12 mu
tants contained at least one transversion mutation each, We speculate that
the increase of TBM in liver and adipose tissue with age is due to chronic
mutagen exposure, perhaps derived From fat in the diet. Environ. Mol. Mutag
en. 33: 320-324, 1999 (C) 1999 Wiley-Liss, Inc.