Inhibitors of human neutrophil elastase as a potential treatment for inflammatory diseases

Authors
Metz, WA Peet, NP
Citation
Wa. Metz et Np. Peet, Inhibitors of human neutrophil elastase as a potential treatment for inflammatory diseases, EXPERT OP T, 9(7), 1999, pp. 851-868
Citations number
71
Categorie Soggetti
Pharmacology & Toxicology
Journal title
EXPERT OPINION ON THERAPEUTIC PATENTS
ISSN journal
13543776 → ACNP
Volume
9
Issue
7
Year of publication
1999
Pages
851 - 868
Database
ISI
SICI code
1354-3776(199907)9:7<851:IOHNEA>2.0.ZU;2-B
Abstract
Inhibition of human neutrophil elastase (HNE), (EC 3.4.21.37), as an approa ch to the treatment of inflammatory diseases in the chronic obstructive pul monary disease (COPD) continuum, such as emphysema and chronic bronchitis, is still an area of intense research within the pharmaceutical industry. Th is review summarises some recent developments in the design and evaluation of HNE inhibitors as therapeutic agents since the subject was last reviewed in this publication in 1997.