Progesterone receptor agonists and antagonists

Steroidal progestin agonists have long been used in oral contraceptives, an d the progestin antagonist mifepristone is used as an abortifacient. Proges tin antagonists are also likely to be useful for treating breast cancer and various gynaecological disorders. This patent review relates to progestin receptor agonists and antagonists, focusing on applications filed over the past three years. Two emerging themes will be elaborated upon: the developm ent of novel steroidal and non-steroidal compounds, and the elucidation of new therapeutic uses for progestin antagonists.