H. Tashiro et al., A follicle-stimulating hormone-secreting gonadotroph adenoma with ovarian enlargement in a 10-year-old girl, FERT STERIL, 72(1), 1999, pp. 158-160
Objective: To report a rare case of gonadotroph adenoma accompanied by ovar
ian enlargement in a child.
Design: Case report.
Setting: A university hospital.
Patient(s): A 10-year-old Japanese girl with multiple cysts of both ovaries
.
Intervention(s): Endocrinologic assays, immunohistochemical staining, ultra
structural observations, and in vitro analysis.
Main Outcome Measure(s): The endocrinologic assays showed an elevated serum
FSH level. The tumor cells excised from the gonadotroph adenoma were immun
ohistochemically positive for antihuman FSH monoclonal antibody. When cultu
red in vitro, the tumor cells secreted FSH in the primary culture.
Result(s): The gonadotroph adenoma produced FSH. After transsphenoidal surg
ery, both ovaries decreased in size.
Conclusion(s): The ovarian enlargement was induced by endogenous FSH from t
he gonadotroph adenoma. To our knowledge, this is the first reported case o
f gonadotroph adenoma accompanied by ovarian enlargement in childhood or ad
olescence. (Fertil Steril(R) 1999;72:158-60. (C) 1999 by American Society f
or Reproductive Medicine.)