A follicle-stimulating hormone-secreting gonadotroph adenoma with ovarian enlargement in a 10-year-old girl

Citation
H. Tashiro et al., A follicle-stimulating hormone-secreting gonadotroph adenoma with ovarian enlargement in a 10-year-old girl, FERT STERIL, 72(1), 1999, pp. 158-160
Citations number
9
Categorie Soggetti
Reproductive Medicine","da verificare
Journal title
FERTILITY AND STERILITY
ISSN journal
00150282 → ACNP
Volume
72
Issue
1
Year of publication
1999
Pages
158 - 160
Database
ISI
SICI code
0015-0282(199907)72:1<158:AFHGAW>2.0.ZU;2-W
Abstract
Objective: To report a rare case of gonadotroph adenoma accompanied by ovar ian enlargement in a child. Design: Case report. Setting: A university hospital. Patient(s): A 10-year-old Japanese girl with multiple cysts of both ovaries . Intervention(s): Endocrinologic assays, immunohistochemical staining, ultra structural observations, and in vitro analysis. Main Outcome Measure(s): The endocrinologic assays showed an elevated serum FSH level. The tumor cells excised from the gonadotroph adenoma were immun ohistochemically positive for antihuman FSH monoclonal antibody. When cultu red in vitro, the tumor cells secreted FSH in the primary culture. Result(s): The gonadotroph adenoma produced FSH. After transsphenoidal surg ery, both ovaries decreased in size. Conclusion(s): The ovarian enlargement was induced by endogenous FSH from t he gonadotroph adenoma. To our knowledge, this is the first reported case o f gonadotroph adenoma accompanied by ovarian enlargement in childhood or ad olescence. (Fertil Steril(R) 1999;72:158-60. (C) 1999 by American Society f or Reproductive Medicine.)