APPROACHES TO THE DIAGNOSIS AND STUDIES O F LEUKEMIAS AFTER THE CHERNOBYL ACCIDENT

Studies of leukemias occurring after the Chernobyl accident imply a nu mber of fundamental and applied aspects: epidemiology, introduction of modern diagnostic methods in clinical practice, study of the contribu tion of target cells to the origin of leukemias, gene mutations, mecha nisms of apoptosis, and cell delay in the G(1) phase of cell cycle, th e oncogene expression, and changes in the cell elements of the bone ma rrow microenvironment. The authors present the experience gained at th e Reference Laboratory for Verifying the Diagnosis of Leukemia and Mye lodysplastic Syndrome. This laboratory is the first in the Ukraine. Du ring 2.5 years more than 800 children and adults with hemoblastoses ha ve been examined here using immunocytochemical methods, monoclonal ant ibody panels, lectins, and biotin-labeled oligosaccharide probes.