LSD and cannabis abuse in early pregnancy with good perinatal outcome: Case report and review of the literature

This is a case report of a 27-year-old patient who had smoked a joint (cann abis) and 20 cigarettes (tobacco) daily up to the time of a positive pregna ncy test at 7 4/7 weeks (p.c.). On day 20 p.c. she had an LSD minitrip. The re are reports of chromosome aberrations in in vitro animal studies with LS D. in humans the main consequences are malformations of the fetal extremiti es and dysplasias of the eye. In both animals and humans cannabis causes ch anges in dopaminergic activity. Our recommendation was to continue the preg nancy, but to monitor it closely. The patient had a spontaneous term delive ry - a lively boy with weight between the 5th and the 50th percentile, leng th between the 50th and the 90th percentile, normal umbilical arteria[ and venous pH values, and Apgar scores 7/9/10. There were no visible abnormalit ies, and behaviour was normal. If it is suspected that a pregnant patient c onsumes LSD, dysplasias of the fetal skeleton and eye should be checked for , With respect to LSD and to cannabis, too, the intellectual development of the child should be closely followed.