BACKGROUND: Interstitial pregnancies are often associated with signifi
cant morbidity. The surgical treatment of such ectopic gestations ofte
n requires laparotomy and cornual resection, thus obliterating tubal a
nd uterine continuity. Methotrexate has been shown to be 94% successfu
l in the management of tubally implanted ectopic gestations, but few r
eports describe its use in interstitial pregnancies. CASE: An 18-year-
old woman who presented with an asymptomatic interstitial pregnancy wa
s treated successfully with intramuscular methotrexate. Laparotomy and
cornual resection were avoided. No adverse effects were noted. CONCLU
SION: Interstitial pregnancies can be treated successfully with intram
uscular methotrexate.