Practical synthesis of 2-pyridone core: Ethyl 8-chloro-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizinone-3-carboxylate

Authors
Li, Q Sowin, T Claiborne, A Lijewski, L Zhang, XL Raye, K Mazdiyasni, H Arnold, W Melcher, LM Wang, WB Hasvold, L Fung, A Chu, DTW Plattner, JJ
Citation
Q. Li et al., Practical synthesis of 2-pyridone core: Ethyl 8-chloro-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizinone-3-carboxylate, HETEROCYCLE, 51(6), 1999, pp. 1345
Citations number
12
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
51
Issue
6
Year of publication
1999
Database
ISI
SICI code
0385-5414(19990601)51:6<1345:PSO2CE>2.0.ZU;2-0
Abstract
A practical synthesis of the fluoropyridone core (2), an important intermed iate to ABT-719 and other 2-pyridones, from the commercially available 3-ch lorotetrafluoropyridine in 10 to 11 linear transformations with 10-26% over all yield is described.