Highly enantioselective addition of dialkylzincs to aromatic aldehydes using 1-phenyl-2-(1-pyrrolidinyl)-1-propanol as a chiral catalyst

Authors
Soai, K Konishi, T Shibata, T
Citation
K. Soai et al., Highly enantioselective addition of dialkylzincs to aromatic aldehydes using 1-phenyl-2-(1-pyrrolidinyl)-1-propanol as a chiral catalyst, HETEROCYCLE, 51(6), 1999, pp. 1421
Citations number
26
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
51
Issue
6
Year of publication
1999
Database
ISI
SICI code
0385-5414(19990601)51:6<1421:HEAODT>2.0.ZU;2-Z
Abstract
(1S,2R)- and (1R,2S)-1-phenyl-2-(1-pyrrolidinyl)-1-propanol catalyzes the e nantioselective addition of dialkylzincs to aromatic aldehydes to afford en antiomerically enriched aromatic sec-alcohols with up to 92% enantiomeric e xcess.