Characterization of a polymorphism in the coding region of the human C5a anaphylatoxin receptor

A polymorphism was identified in the coding region of the human C5a anaphyl atoxin receptor gene leading to C to T transition at nucleotide position 45 0 (a silent substitution in the Ala(150) codon, GCC to GCT). Its distributi on was studied in a population of healthy volunteers from the Quebec city r egion (prevalence of 2.8%) and among patients with end-stage renal failure who had previously undergone renal graft (prevalence 1.4%, not significantl y different from that of the control group). This new marker provides a val uable tool to assess the risk for putative C5a-associated disorders with ge netic determinism.