Importance of retrograde atrial activation in atrial fibrillation genesis in the initiation of atrial fibrillation in Wolff-Parkinson-White syndrome - Comparison of atrial electrophysiologic parameters between patients with different atrial fibrillation genesis (initiation sites) in atria

The changes in the duration of atrial electrograms during different atrial activation sequences from a sinus rhythm were evaluated to test the hypothe sis that the prolongation of atrial electrogram duration caused by the diff erent atrial activation sequence is more prominent at the site of atrial fi brillation (Afib) genesis (initiation site) than other areas. In 39 patients with single retrogade left-sided accessory connection who ha d inducible transient atrial fibrillation during an electrophysiologic stud y, the site of Afib genesis was determined and classified into three groups , i.e., 1) high right atrial genesis (HRA), 2) low right atrial genesis (LR A), and 3) left atrial genesis (LA). Single premature extrastimuli after 8 basic drive trains (600 ms) were delivered at the HRA and the right ventric ular apex. Three atrial electrophysiologic parameters were evaluated at thr ee atrial sites, i.e., 1) HRA, 2) LRA, and 3) coronary sinus. The atrial vu lnerability parameters were as follows; 1) %A2/A1: % prolongation of atrial electrogram duration during premature beat (A2) in comparison with basic d rive (A1), 2) wavelength index (WLI): calculated as [effective refractory p eriod]/[A2], and 3) retrograde activation index (RAI): calculated as [A1 du ring retrograde activation; i.e., RVA pacing/[A1 during antegrade activatio n, i.e., HRA pacing], shown as a percentage. The Afib genesis was HRA in 20, LRA in 12 and LA in 7 patients. At the HRA recording site, %A2/A1 and RAI were the largest and WLI the shortest in the HRA genesis group in comparison with the other two groups. Similarly, at t he LRA and LA recording sites, %A2/A1 and RAI were the largest and WLI the shortest in the groups with Afib genesis at these recording sites. In patients with inducible Afib, %A2/A1 and RAI were the highest and WLI th e shortest at the atrial recording site close to the site of Afib genesis. Atrial wave prolongation during retrograde atrial activation, possibly the anisotropic conduction, was considered to play a role in initiating Afib as well as a conduction delay during the atrial premature beat.