Effects of the aqueous extract of Bridelia ferruginea stem bark on carrageenan-induced oedema and granuloma tissue formation in rats and mice

The anti-inflammatory activity of the aqueous extract of the stem bark of B ridelia ferruginea was evaluated using carrageenan-induced paw oedema in ra ts and mice, and the cotton pellet granuloma method. The extract at doses r anging from 10 to 80 mg/kg p.o. significantly inhibited the carrageenan-ind uced rat paw oedema, with an ID50 value of 36 mg/kg. However, a low activit y was produced in the mouse paw oedema. The extract also suppressed the gra nulomatous tissue formation of chronic inflammation. B. ferruginea therefor e proved to be effective in both the acute and chronic phases of the inflam matory process. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.