Effects of dietary inulin on serum lipids

Inulin is a carbohydrate belonging to a class of compounds known as fructan s. Because inulin is resistant to digestion in the upper gastrointestional tract it reaches the large intestine essentially intact, where it is fermen ted by indigenous bacteria. Thus, it may be classified as a soluble dietary fiber, Soluble fibers have been shown to modulate serum lipids. A recent s tudy examined the effect of consuming three servings per day of inulin-cont aining foods, compared with the effect of similar foods without inulin, on serum lipid profiles among hypercholesterolemic men and women. In addition, the practicality of including 18 g/d of inulin in a low fat diet was inves tigated. The recent study randomized, double-blind, crossover trial with tw o 6-wk treatment periods, separated by a 6-wk washout. Men and women (n = 2 1) with baseline LDL increased significantly (7.4 and 12.3%, respectively) during the control phase. There were small, nonsignificant declines in tota l (1.3%) and LDL-C (2.1%) during the inulin phase. Thus, differences in res ponse between periods (inulin - control) were significant (P < 0.05) for LD L-C (-14.4%) and total cholesterol (-8.7%). Mild gastrointestinal discomfor t was more common during the inulin than the control food phase; however, t he gastrointestinal side-effect profile of inulin was similar to that of ot her soluble fibers. Although it was not possible to draw firm conclusions, inulin may have blunted the hypercholesterolemic effects observed during co nsumption of control foods. Additional research will be required to confirm the possible lipid-modulating properties of dietary inulin in humans.