Normal- and reversed-phase thin-layer chromatography of tosylated xylitol derivatives

The chromatographic behavior of a series of tosylated xylitol derivatives h as been studied on silica gel and on C-8- and C-18-modified silica gel laye rs with, respectively, binary nonaqueous and aqueous mobile phases. The slo pes and intercepts of the linear relationships between the retention consta nt (R-M) and the logarithm of the volume fraction of the polar component of the nonaqueous mobile phase, and of the volume fraction of organic compone nt of the aqueous-organic mobile phase, have been calculated and are discus sed in relation to the properties of the solute and of the mobile and stati onary phases. The retention and relative retention of compounds depend larg ely on the retention behavior of their substituents.