Molecular bases of drug design for AIDS treatment: Achievements and prospects

Authors
Krayevsky, AA
Citation
Aa. Krayevsky, Molecular bases of drug design for AIDS treatment: Achievements and prospects, MOL BIOL, 33(3), 1999, pp. 295-303
Citations number
47
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MOLECULAR BIOLOGY
ISSN journal
00268933 → ACNP
Volume
33
Issue
3
Year of publication
1999
Pages
295 - 303
Database
ISI
SICI code
0026-8933(199905/06)33:3<295:MBODDF>2.0.ZU;2-9
Abstract
The current state of chemotherapeutic treatment of AIDS in terms of the mol ecular mechanisms of the drug action is analyzed and its prospects are disc ussed. A concise overview of the data of the author's laboratory is given. Intracellular phosphorylation-independent nucleotide inhibitors of reverse transcription and replication of proviral HIV RNA in cell-free systems and cell cultures are described.