Use of functionally competent nucleoside and nucleotide analogs in studying enzyme-substrate interactions

Authors
Mikhailov, SN Lysov, YP Yakovlev, GI
Citation
Sn. Mikhailov et al., Use of functionally competent nucleoside and nucleotide analogs in studying enzyme-substrate interactions, MOL BIOL, 33(3), 1999, pp. 340-354
Citations number
83
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MOLECULAR BIOLOGY
ISSN journal
00268933 → ACNP
Volume
33
Issue
3
Year of publication
1999
Pages
340 - 354
Database
ISI
SICI code
0026-8933(199905/06)33:3<340:UOFCNA>2.0.ZU;2-Z
Abstract
The preparation of C'-methylnucleosides and their phosphoric esters as well as their physicochemical and substrate properties in various enzymic react ions are reviewed. The use of functionally competent analogs for the determ ination of the substrate conformation during enzymic reactions is summarize d.