Jd. Wang et Js. Weissman, Thinking outside the box: new insights into the mechanism of GroEL-mediated protein folding, NAT ST BIOL, 6(7), 1999, pp. 597-600
GroEL is thought to assist protein folding in part by providing a passive '
box' in which folding can occur without danger of aggregation. Two new pape
rs now suggest that GroEL can also play a more active role by promoting rea
rrangement and even unfolding of kinetic folding intermediates.