Mt. Witt et al., Kawasaki disease: More patients are being diagnosed who do not meet American Heart Association criteria, PEDIATRICS, 104(1), 1999, pp. E101-E105
Objective. To determine the frequency of Kawasaki disease (KD) diagnosis in
patients who did and did not meet American Heart Association (AHA) diagnos
tic criteria and to examine the clinical findings, the time to treatment, a
nd the outcomes of the two groups.
Design. Retrospective review of all patients with a discharge diagnosis of
KD at a tertiary care children's hospital (1991-1997),
Results. A total of 127 patients were identified. All received intravenous
immune globulin (IVIG) and had complete echocardiographic studies. AHA crit
eria were met in 81 (63.8%). More patients who did not meet criteria (9 of
46, 20%) had coronary artery abnormalities (CAA), compared with those who h
ad the complete clinical picture (6 of 81, 7%). The 15 patients with CAA re
ceived IVIG later (12.4 +/- 7.4 days) from onset of symptoms compared with
those with no CAA (8.2 +/- 4.6). The time period was the same for patients
with CAA who met the criteria, (11.8 +/- 5.8 days) as for patients who did
not meet AHA criteria (12.5 +/- 8.6 days). Infants were more likely than we
re older children to develop CAA, to receive IVIG later, and to be diagnose
d with an incomplete clinical picture.
Conclusion. Physicians are increasingly likely to diagnose KD in patients w
ho do not meet complete AHA criteria. Despite the potential risks of overdi
agnosis and overtreatment, this practice seems justified because the comple
te criteria are;in insensitive indicator of having or developing CAA.