Adrenomedullin-like immunoreactivity in the rat hypothalamoneurohypophysial tract

Authors
Ueta, Y Hara, Y Setiadji, VS Isse, T Shibuya, I Kitamura, K Kangawa, K Matsuo, H Eto, T Hattori, Y Yamashita, H
Citation
Y. Ueta et al., Adrenomedullin-like immunoreactivity in the rat hypothalamoneurohypophysial tract, PEPTIDES, 20(2), 1999, pp. 199-204
Citations number
22
Categorie Soggetti
Biochemistry & Biophysics
Journal title
PEPTIDES
ISSN journal
01969781 → ACNP
Volume
20
Issue
2
Year of publication
1999
Pages
199 - 204
Database
ISI
SICI code
0196-9781(1999)20:2<199:AIITRH>2.0.ZU;2-R
Abstract
Adrenomedullin-like immunoreactivity in the hypothalamo-neurohypophysial tr act in colchicine-treated and hypophysectomized rats was examined by immuno histochemistry. Adrenomedullin-like immunoreactive (AM-LI) neurons were loc alized in the hypothalamic areas, including the paraventricular nuclei and the supraoptic nuclei. Abundant AM-LI fibers and varicosities were found in the hypothalamoneurohypophysial tract and the internal zone of the median eminence in the colchicine-treated and hypophysectomized rats, whereas in c ontrol rats few AM-LI fibers were observed. These results suggest that the axons of the AM-LI neurons in the hypothalamus may terminate in the neurohy pophysis. (C) 1999 Elsevier Science Inc. All rights reserved.