Antimalarial activity and cytotoxicity of (-)-roemrefidine isolated from the stem bark of Sparattanthelium amazonum

Authors
Munoz, V Sauvain, M Mollinedo, P Callapa, J Rojas, I Gimenez, A Valentin, A Mallie, M
Citation
V. Munoz et al., Antimalarial activity and cytotoxicity of (-)-roemrefidine isolated from the stem bark of Sparattanthelium amazonum, PLANTA MED, 65(5), 1999, pp. 448-449
Citations number
9
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
00320943 → ACNP
Volume
65
Issue
5
Year of publication
1999
Pages
448 - 449
Database
ISI
SICI code
0032-0943(199906)65:5<448:AAACO(>2.0.ZU;2-D
Abstract
(-)-Roemrefidine, an aporphine alkaloid isolated from Sparattanthelium amaz onum Martius (Hernandiaceae) a vine from Bolivia, has been found to be acti ve against both resistant and sensitive strains of Plasmodium falciparum in vitro and against P. berghei in mice. The compound demonstrated no cytotox ic activity against three cell lines (KB, HEp-2 and HeLa).