A. Becker et al., Social behaviour in rats lesioned with ibotenic acid in the hippocampus: quantitative and qualitative analysis, PSYCHOPHAR, 144(4), 1999, pp. 333-338
Rationale: Neonatal ibotenic acid lesion of the ventral hippocampus was pro
posed as a relevant animal model of schizophrenia reflecting positive as we
ll as negative symptoms of this disease. Before and after reaching maturity
, specific alterations in the animals' social behaviour were found. Objecti
ve: In this study, social behaviour of ventral hippocampal lesioned rats wa
s analysed. For comparison, rats lesioned either in the ventral hippocampus
or the dorsal hippocampus at the age of 8 weeks were tested. Methods: Rats
on day 7 of age were lesioned with ibotenic acid in the ventral hippocampu
s and social behaviour was tested at the age of 13 weeks. For comparison, a
dult 8-week-old rats were lesioned either in the ventral or the dorsal hipp
ocampus. Their social behaviour was tested at the age of 18 weeks. Results:
It was found that neonatal lesion resulted in significantly decreased time
spent in social interaction and an enhanced level of aggressive behaviour.
This shift is not due to anxiety because we could not find differences bet
ween control rats and lesioned rats in the elevated plus-maze. Lesion in th
e ventral and dorsal hippocampus, respectively, in 8-week-old rats did not
affect social behaviour. Conclusions: The results of our study indicate tha
t ibotenic acid-induced hippocampal damage per se is not related to the shi
ft in social behaviour. We favour the hypothesis that these changes are due
to lesion-induced impairments in neurodevelopmental processes at an early
stage of ontogenesis.