Kelletinin A, from the marine mollusc Buccinulum corneum, promotes differentiation in Hydra vulgaris

Authors
De Petrocellis, L Orlando, P Pierobon, P De Falco, M Ruggiero, AM Stefano, GSMD Tino, A Grippo, P
Citation
L. De Petrocellis et al., Kelletinin A, from the marine mollusc Buccinulum corneum, promotes differentiation in Hydra vulgaris, RES COM M P, 103(1), 1999, pp. 17-28
Citations number
19
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY
ISSN journal
10780297 → ACNP
Volume
103
Issue
1
Year of publication
1999
Pages
17 - 28
Database
ISI
SICI code
1078-0297(199901)103:1<17:KAFTMM>2.0.ZU;2-V
Abstract
The effects of kelletinin A [ribityl pentakis (p-hydroxybenzoate)] (KA), a natural compound isolated from the marine gastropod Buccinulum corneum, wer e studied in vivo in Hydra vulgaris during regeneration. KA caused a marked increase of regenerated tentacle numbers (ATN) and promoted transdifferent iation of epithelial cells into battery cells, and nematocyte differentiati on. Morphological data were correlated to changes in acid and alkaline phos phatase levels, enzymes that have been described as regeneration markers.