Recently, our research group has concentrated our efforts on the study of s
ynthetic utilities of NAD(P)H models. Silica gel was found to effectively a
ctivate substrates and NAD(P)H models and to catalyze reductions with uniqu
e selectivities. In this review, we summarize our recent findings on some h
ighly selective reductions by NAD(P)H models useful for organic synthesis.