Osteogenic sarcoma with skeletal muscle metastases

Two cases of osteogenic sarcoma with skeletal muscle metastases are describ ed. A 40-year-old woman presented with progressive swelling of both calves and a soft tissue back lump. She had been diagnosed with mandibular chondro blastic osteogenic sarcoma 6 years earlier. Radiographs showed calcified ma sses. MRI scans and bone scintigraphy revealed multiple soft tissue masses in both calves. Bone scintigraphy also showed uptake in the back lump, righ t thigh and left lung base. Biopsy confirmed metastatic chondroblastic oste ogenic sarcoma, which initially responded well to chemo therapy. However, t he metastatic disease subsequently progressed rapidly and she died 21 month s after presentation. The second case concerns a 20-year-old man who presen ted with a pathologic fracture of the humerus, which was found to be due to osteoblastic osteogenic sarcoma, He developed cerebral metastases 17 month s later, followed by metastases at other sites. Calcified masses were subse quently seen on radiographs of the abdomen and chest. CT scans confirmed th e presence of densely calcified muscle metastases in the abdominal wall, er ector spinae and gluteal muscles. The patient's disease progressed rapidly and he died 30 months after presentation.