Topically applied tretinoin (a retinoid) has been used for over 25 years to
treat acne and disorders of keratinization. Now, tretinoin emollient cream
, 0.05% (Renova(R)), may be prescribed for the treatment of photodamaged an
d chronologically aged skin, in conjunction with appropriate skin care and
sun protection routines. Mild to moderate cutaneous side effects to topical
tretinoin, such as xerosis, peeling, erythema and subjective irritation, a
re experienced by a majority of patients undergoing retinoid therapy. Resul
ts of clinical compatibility testing show that concomitant use of effective
moisturizers, mild cleansers and daily sunscreens greatly enhance skin tol
erance and patient comfort. A frequently prescribed regimen for topical tre
atment of photodamaged skin includes a combination of tretinoin and glycoli
c acid. While many clinicians report the use of both these agents for the m
anagement of their patients, little information exists in the literature ab
out their compatibility in concomitant use. The results of a double-blind c
linical study demonstrate that daytime usage of one of two 8% glycolic acid
lotions in addition to nightly applications of Renova was well tolerated a
s part of a comprehensive skin care and sun protection program.