Total syntheses of trichodenones A-C

Both enantiomers of trichodenones A, and B and C, the cytotoxic metabolites from a strain of Trichoderma harzianum from the sponge Halichondria okadai , have been synthesized from (R)- and (S)-4-hydroxy-2-cyclopentenones as ch iral building blocks, respectively. These syntheses allowed assignment of a bsolute stereostructures for these natural products.