Biosynthesis of the marine cyanobacterial metabolite barbamide. 2: Elucidation of the origin of the thiazole ring by application of a new GHNMBC experiment

Authors
Williamson, RT Sitachitta, N Gerwick, WH
Citation
Rt. Williamson et al., Biosynthesis of the marine cyanobacterial metabolite barbamide. 2: Elucidation of the origin of the thiazole ring by application of a new GHNMBC experiment, TETRAHEDR L, 40(28), 1999, pp. 5175-5178
Citations number
10
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
28
Year of publication
1999
Pages
5175 - 5178
Database
ISI
SICI code
0040-4039(19990709)40:28<5175:BOTMCM>2.0.ZU;2-P
Abstract
A new NMR experiment is presented for the detection of intact C-13-N-15 uni ts in biosynthetic studies. Its use is demonstrated through a feeding exper iment utilizing [2-C-13,N-15] glycine which confirmed the origin of the thi azole ring in the marine cyanobacterial metabolite barbamide as originating from cysteine. (C) 1999 Elsevier Science Ltd. All rights reserved.