Successful myoblast transplantation in fibrotic muscles: No increased impairment by the connective tissue

Citation
V. Brussee et al., Successful myoblast transplantation in fibrotic muscles: No increased impairment by the connective tissue, TRANSPLANT, 67(12), 1999, pp. 1618-1622
Citations number
10
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
TRANSPLANTATION
ISSN journal
00411337 → ACNP
Volume
67
Issue
12
Year of publication
1999
Pages
1618 - 1622
Database
ISI
SICI code
0041-1337(19990627)67:12<1618:SMTIFM>2.0.ZU;2-Q
Abstract
Backgrounds. Implantation of normal myoblasts may eventually be a treatment for inherited myopathies such as Duchenne muscular dystrophy. Methods. We report a comparative study of the effectiveness on myoblast implantation: ( 1) into the muscles of young (2 months) mdx mice nonirradiated and noninjec ted with notexin (group 1), (2) into muscles of old mdx mice (15 months) no nirradiated and noninjected with notexin (group 2), and (3) into muscles of 5 months mdx mice irradiated 3 months before the transplantation (group 3) . Roughly 3 million cells were injected with bFGF in the Tibialis anterior. Results. Although mice of groups 2 and 3 had significantly more (P<0.05) f ibrotic tissue in their muscles than those of group I, the transplantation success was not significantly different among the three groups. Conclusion. Therefore these results demonstrated that myoblast transplantation can be successful even when there is abundant fibrosis.