The role of genomic imprinting of G(s)alpha in the pathogenesis of Albright hereditary osteodystrophy

Authors
Weinstein, LS Yu, SH
Citation
Ls. Weinstein et Sh. Yu, The role of genomic imprinting of G(s)alpha in the pathogenesis of Albright hereditary osteodystrophy, TRENDS ENDO, 10(3), 1999, pp. 81-85
Citations number
40
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
TRENDS IN ENDOCRINOLOGY AND METABOLISM
ISSN journal
10432760 → ACNP
Volume
10
Issue
3
Year of publication
1999
Pages
81 - 85
Database
ISI
SICI code
1043-2760(199904)10:3<81:TROGIO>2.0.ZU;2-R
Abstract
Albright hereditary osteodystrophy (AHO) is caused by heterozygous inactiva ting mutations of the gene encoding the alpha-subunit of the G protein G(s) . The G(s)alpha gene is a complex gene that uses various alternative promot ers and produces various protein products. Recently it has been shown that this gene is imprinted in a tissue-specific manner The role of tissue-speci fic imprinting of G(s)alpha in the pathogenesis of AHO is discussed.