Mechanisms by which thiazolidinediones enhance insulin action

Authors
Reginato, MJ Lazar, MA
Citation
Mj. Reginato et Ma. Lazar, Mechanisms by which thiazolidinediones enhance insulin action, TRENDS ENDO, 10(1), 1999, pp. 9-13
Citations number
72
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
TRENDS IN ENDOCRINOLOGY AND METABOLISM
ISSN journal
10432760 → ACNP
Volume
10
Issue
1
Year of publication
1999
Pages
9 - 13
Database
ISI
SICI code
1043-2760(199901/02)10:1<9:MBWTEI>2.0.ZU;2-7
Abstract
Thiazolidinediones (TZDs) are an exciting new class of insulin-sensitizing drugs being used currently for the treatment of non-insulin-dependent diabe tes mellitus. The molecular target of these compounds is thought to be the nuclear hormone receptor peroxisome proliferator-activated receptor gamma ( PPAR gamma). PPAR gamma is expressed predominantly in adipose tissue, yet a major site of TZD-responsive glucose disposal is skeletal muscle. Potentia l explanations for this paradox are discussed in this review.