Targeting phthalocyanines to tumor cells using epidermal growth factor conjugates

Authors
Lutsenko, SV Feldman, NB Finakova, GV Posypanova, GA Severin, SE Skryabin, KG Kirpichnikov, MP Lukyanets, EA Vorozhtsov, GN
Citation
Sv. Lutsenko et al., Targeting phthalocyanines to tumor cells using epidermal growth factor conjugates, TUMOR BIOL, 20(4), 1999, pp. 218-224
Citations number
16
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
TUMOR BIOLOGY
ISSN journal
10104283 → ACNP
Volume
20
Issue
4
Year of publication
1999
Pages
218 - 224
Database
ISI
SICI code
1010-4283(199907/08)20:4<218:TPTTCU>2.0.ZU;2-I
Abstract
Epidermal growth factor (EGF) was used as a vector for targeted delivery of phthalocyanines to tumor cells. The conjugates of EGF with disulfochloride aluminum phthalocyanine [Pc(AI)I and disulfochloride cobalt phthalocyanine [Pc(Co)] were synthesized. The cytotoxic activity of the conjugates agains t the human breast carcinoma cell line MCF-7 was determined. The cytotoxic activity of the EGF-Pc(Co) conjugate was 4.5 times higher than that of the EGF-Pc(AI) conjugate. The antitumor activity of the EGF-Pc(Co) conjugate wa s also studied in vivo in murine melanoma B16. Compared to free Pc(Co), int ravenous injections of Pc(Co) conjugated with EGF inhibited tumor developme nt and increased mean life span and mean survival time of experimental anim als.