Experimental study of the effect of different meshes on bacterial translocation

Implantation of intraabdominal biomaterials promotes bacterial translocatio n (BT). In this study we planned to determine the effect of different types of mesh on the induction of BT. Swiss albino mice were divided into four g roups: control, polypropylene (PP), polyglactin 910 (PG), and dura mater (D M). At hour 0, an abdominal wall defect was created in all animals. In the control group the defect was closed primarily. PP, PG, and DM meshes were u sed to repair the defects such that the intestines were in contact with the mesh in the remaining three groups. BT was evaluated 4, 24, and 48 hours l ater. At 4 hours total BT increased in the PP group compared with that in t he control (p = 0.0321) and DM (p = 0.0098) groups. At 24 hours the PG grou p had increased BT compared with the controls (p = 0.0392) and the DM group (p = 0.0274), whereas the PP group had increased BT compared with the DM g roup only (p = 0.0477). At 48 hours both PG and PP groups had increased BT compared with controls (p = 0.0431 and p = 0.0001, respectively); the PP gr oup had also increased BT compared to the DM group (p = 0.001) and the PG g roup (p = 0.017). In the control, DM, and PP groups there was no intragroup statistical difference. In the PG group there was a significant increase i n BT at 24 hours compared to that at 4 hours (p = 0.0274). Prosthetic meshe s led to increased BT compared to that with the DM mesh. This effect might be attributed to the different organic and physical properties of the meshe s.