The uncommon causes of anterior knee pain should always he considered in th
e differential diagnosis of a painful knee when treatment of common origins
become ineffective. A case is presented in which the revised diagnosis of
infrapatellar contracture syndrome was made after noting delayed progress i
n the rehabilitation of an active female patient with a presumed anterior h
orn medial meniscus tear and a contracted patellar tendon. The patient impr
oved after the treatment program was augmented with closed manipulation und
er arthroscopy and infrapatellar injection of both corticosteroids and a lo
cal anesthetic. Infrapatellar contraction syndrome and other uncommon sourc
es of anterior knee pain, including arthrofibrosis, Hoffa's syndrome, tibia
l collateral ligament bursitis, saphenous nerve palsy, isolated ganglions o
f the anterior cruciate ligament, slipped capital femoral epiphysis, and kn
ee tumors, are subsequently discussed. Delayed functional advancement in a
rehabilitation program requires full reassessment of the patient's diagnosi
s and treatment plan. Alternative diagnoses of knee pain are not always of
common origins. Ample knowledge of uncommon causes of anterior knee pain is
necessary to form a full differential diagnosis in patients with challengi
ng presentations.