Ke. Yarasheski et al., Resistance exercise training increases mixed muscle protein synthesis ratein frail women and men >= 76 yr old, AM J P-ENDO, 40(1), 1999, pp. E118-E125
Citations number
33
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
Muscle atrophy (sarcopenia) in the elderly is associated with a reduced rat
e of muscle protein synthesis. The purpose of this study was to determine i
f weight-lifting exercise increases the rate of muscle protein synthesis in
physically frail 76- to 92-yr-old women and men. Eight women and 4 men wit
h mild to moderate physical frailty were enrolled in a 3-mo physical therap
y program that was followed by 3 mo of supervised weight-lifting exercise.
Supervised weight-lifting exercise was performed 3 days/wk at 65-100% of in
itial 1-repetition maximum on five upper and three lower body exercises. Co
mpared with before resistance training, the in vivo incorporation rate of [
C-13]leucine into vastus lateralis muscle protein was increased after resis
tance training in women and men (P < 0.01), although it was unchanged in fi
ve 82 +/- 2-yr-old control subjects studied two times in 3 ma. Maximum volu
ntary knee extensor muscle torque production increased in the supervised re
sistance exercise group. These findings suggest that muscle contractile pro
tein synthetic pathways in physically frail 76- to 92-yr-old women and men
respond and adapt to the increased contractile activity associated with pro
gressive resistance exercise training.