Resistance exercise training increases mixed muscle protein synthesis ratein frail women and men >= 76 yr old

Citation
Ke. Yarasheski et al., Resistance exercise training increases mixed muscle protein synthesis ratein frail women and men >= 76 yr old, AM J P-ENDO, 40(1), 1999, pp. E118-E125
Citations number
33
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
ISSN journal
01931849 → ACNP
Volume
40
Issue
1
Year of publication
1999
Pages
E118 - E125
Database
ISI
SICI code
0193-1849(199907)40:1<E118:RETIMM>2.0.ZU;2-R
Abstract
Muscle atrophy (sarcopenia) in the elderly is associated with a reduced rat e of muscle protein synthesis. The purpose of this study was to determine i f weight-lifting exercise increases the rate of muscle protein synthesis in physically frail 76- to 92-yr-old women and men. Eight women and 4 men wit h mild to moderate physical frailty were enrolled in a 3-mo physical therap y program that was followed by 3 mo of supervised weight-lifting exercise. Supervised weight-lifting exercise was performed 3 days/wk at 65-100% of in itial 1-repetition maximum on five upper and three lower body exercises. Co mpared with before resistance training, the in vivo incorporation rate of [ C-13]leucine into vastus lateralis muscle protein was increased after resis tance training in women and men (P < 0.01), although it was unchanged in fi ve 82 +/- 2-yr-old control subjects studied two times in 3 ma. Maximum volu ntary knee extensor muscle torque production increased in the supervised re sistance exercise group. These findings suggest that muscle contractile pro tein synthetic pathways in physically frail 76- to 92-yr-old women and men respond and adapt to the increased contractile activity associated with pro gressive resistance exercise training.