J. Menezes et al., A novel nitric oxide scavenger decreases liver injury and improves survival after hemorrhagic shock, AM J P-GAST, 40(1), 1999, pp. G144-G151
Citations number
34
Categorie Soggetti
da verificare
Journal title
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
We tested the ability of a nitric oxide (NO) scavenger to reduce tissue inj
ury in a rodent model of hemorrhagic shock. Rats were hemorrhaged to a mean
arterial blood pressure (MAP) of 40 mmHg and then resuscitated when either
30% of their shed blood had been returned (group I) or after 100 min of co
ntinuous shock (group 2). Selected animals were treated with the NO scaveng
er NOX (30 mg.kg(-1).h(-1)) infused over 4 h. Hemorrhaged rats had a lower
MAP after resuscitation compared with sham-shock control rats. NOX treatmen
t significantly increased MAP after resuscitation from hemorrhage. Hemorrha
gic shock also increased liver injury as reflected by elevated ornithine ca
rbamoyltransferase (OCT) plasma levels, and NOX treatment significantly red
uced OCT release. In addition, NOX was associated with significantly decrea
sed hepatic neutrophil infiltration and improved 24-h survival (n. = 8 of 9
) compared with saline-treated shock animals (n 3 of 9). These data suggest
that excess NO mediates shock-induced tissue injury and that suppression o
f NO availability with NO scavengers may reduce the pathophysiological sequ
elae of severe hemorrhage.