Short report: Prevention of Schistosoma mansoni infections in mice by the insect repellents AI3-37220 and N,N-diethyl-3-methylbenzamide

Authors
Secor, WE Freeman, GL Wirtz, RA
Citation
We. Secor et al., Short report: Prevention of Schistosoma mansoni infections in mice by the insect repellents AI3-37220 and N,N-diethyl-3-methylbenzamide, AM J TROP M, 60(6), 1999, pp. 1061-1062
Citations number
10
Categorie Soggetti
Envirnomentale Medicine & Public Health","Medical Research General Topics
Journal title
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
ISSN journal
00029637 → ACNP
Volume
60
Issue
6
Year of publication
1999
Pages
1061 - 1062
Database
ISI
SICI code
0002-9637(199906)60:6<1061:SRPOSM>2.0.ZU;2-H
Abstract
N,N-diethyl-3-methylbenzamide (DEET) has recently been reported to kill cer cariae of Schistosoma mansoni in vitro. In addition, it blocked cercarial e ntry into mouse tail skin. We confirmed these results and compared the effi cacy of DEET to a second insect repellent, 1-(3-Cyclohexen-1-yl-carbonyl)-2 -methylpiperidine (AI3-37220), in preventing S. mansoni infections in mice. Both AI3-37220 and DEFT conferred 100% protection against S. mansoni infec tion via percutaneous exposure to cercariae.