Leiomyosarcoma of the larynx - Review of the literature and report of two cases

Leiomyosarcoma of the larynx is an extremely rare malignancy. Until now, on ly 35 cases have been reported, and only 19 were reported in English. We pr esent 2 new cases observed in the last 3 years at our department. Correct h istologic diagnosis can only be made on immunohistochemical and electron mi croscopic grounds. A 65-year-old man previously treated for a premalignant vocal cord lesion and a 31-year-old woman who previously underwent operatio n on a benign vocal cord lesion are presented. Only surgical treatment (tot al laryngectomy and endolaryngeal laser resection) was performed. Thirty-si x and 22 months after the initial surgical intervention, both patients are alive and well, with no evidence of local recurrence or distant metastasis.