Cm. Nunn et S. Neidle, STRUCTURE OF THE A-DNA OCTAMER D(GGCATGCC), Acta crystallographica. Section D, Biological crystallography, 53, 1997, pp. 269-273
Citations number
20
Categorie Soggetti
Crystallography,"Biochemical Research Methods",Biology
The crystal structure of the self-complementary DNA octamer d(GGCATGCC
) has been determined to a resolution of 2.38 Angstrom and R factor of
17.1%. The structure is an A-DNA octamer duplex with Watson-Crick bas
e pairing along its length. This sequence extends the investigation of
octamer duplexes of the type d(GGX(4)CC) which assume P6(1) packing w
ithin the crystallographic unit cell. The A-DNA duplex is non-linear w
ith a helix axis curvature of 7 degrees and bending towards the DNA mi
nor groove. In view of the biological importance of protein recognitio
n of some A-DNA sequences the minor-groove geometry and helix-axis cur
vature for this structure is compared with all others of the type d(GG
XATXCC).