Synthesis and anti-HIV activity of some novel arylphosphate and H-phosphonate derivatives of 3 '-azido-2 ',3 '-dideoxythymidine and 2 ',3 '-didehydro-2 ',3 '-dideoxythymidine

Authors
Cardona, VMF Ayi, AI Aubertin, AM Guedj, R
Citation
Vmf. Cardona et al., Synthesis and anti-HIV activity of some novel arylphosphate and H-phosphonate derivatives of 3 '-azido-2 ',3 '-dideoxythymidine and 2 ',3 '-didehydro-2 ',3 '-dideoxythymidine, ANTIVIR RES, 42(3), 1999, pp. 189-196
Citations number
20
Categorie Soggetti
Microbiology
Journal title
ANTIVIRAL RESEARCH
ISSN journal
01663542 → ACNP
Volume
42
Issue
3
Year of publication
1999
Pages
189 - 196
Database
ISI
SICI code
0166-3542(199907)42:3<189:SAAAOS>2.0.ZU;2-1
Abstract
Phosphate and H-phosphonate derivatives of anti-HIV nucleoside analogues (A ZT and d4T) were prepared as potential prodrugs of the bio-active free nucl eotide and they were evaluated for their inhibitory effects on the replicat ion of HIV-1 in several cell culture systems. One compound exhibited an imp ortant anti-HIV-l activity and proved to be significantly more efficient th an the parent nucleoside. (C) 1999 Elsevier Science B.V. All rights reserve d.