Synthesis and anti-HIV activity of some novel arylphosphate and H-phosphonate derivatives of 3 '-azido-2 ',3 '-dideoxythymidine and 2 ',3 '-didehydro-2 ',3 '-dideoxythymidine
Vmf. Cardona et al., Synthesis and anti-HIV activity of some novel arylphosphate and H-phosphonate derivatives of 3 '-azido-2 ',3 '-dideoxythymidine and 2 ',3 '-didehydro-2 ',3 '-dideoxythymidine, ANTIVIR RES, 42(3), 1999, pp. 189-196
Phosphate and H-phosphonate derivatives of anti-HIV nucleoside analogues (A
ZT and d4T) were prepared as potential prodrugs of the bio-active free nucl
eotide and they were evaluated for their inhibitory effects on the replicat
ion of HIV-1 in several cell culture systems. One compound exhibited an imp
ortant anti-HIV-l activity and proved to be significantly more efficient th
an the parent nucleoside. (C) 1999 Elsevier Science B.V. All rights reserve
d.