Lung local defense in experimental diabetes mellitus and the effect of 11,20-dihydroxyecdysone in combination with maninil

Disorders of lung local defensive mechanisms were noted in rats with alloxa ne-induced diabetes mellitus, which showed itself as neutrophilic infiltrat ion and decrease of macrophagal bactericidal action in the lungs. All this contributed to the development and chronization of bronchopulmonary inflamm atory diseases. Use of maninil caused further inhibition of cellular and hu moral lung immunity indices. Addition of 11,20-dihydroxyecdysone (turkester one) to the therapy resulted in positive changes in the lung defense mechan isms. (C) 1999 Wiley-Liss, Inc.