Dk. Najmutdinova et Z. Saatov, Lung local defense in experimental diabetes mellitus and the effect of 11,20-dihydroxyecdysone in combination with maninil, ARCH INS B, 41(3), 1999, pp. 144-147
Disorders of lung local defensive mechanisms were noted in rats with alloxa
ne-induced diabetes mellitus, which showed itself as neutrophilic infiltrat
ion and decrease of macrophagal bactericidal action in the lungs. All this
contributed to the development and chronization of bronchopulmonary inflamm
atory diseases. Use of maninil caused further inhibition of cellular and hu
moral lung immunity indices. Addition of 11,20-dihydroxyecdysone (turkester
one) to the therapy resulted in positive changes in the lung defense mechan
isms. (C) 1999 Wiley-Liss, Inc.